Guo was born in Beijing in 1967. Her father was a senior official and her mother a kindergarten teacher. In 1986, she graduated after studying fashion design at the Beijing Second Light Industry School.Three years later, Guo became chief designer at one of Beijing's first independently owned clothing companies in the post-Cultural Revolution era. She left the company in 1997 to form her own fashion brand.
Her “One Thousand and Two Nights” collection debuted in November 2009, during China Fashion Week. American model, Carmen Dell’Orefice appeared in the show wearing an elaborate white embroidered fur-lined gown, with an escort of four to help carry its train. Dell’Orefice later went on to compare Guo to Charles James. Guo was credited as a costume designer on the set of the 2014 film The Monkey King. The film's makeup and costume departments were nominated for a Hong Kong Film Award the following year but lost out to Man Lim Chung, in The Golden Era.